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Article

Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease.

Molecular psychiatry - 1 Oct 2021

Panitch Rebecca, Hu Junming, Chung Jaeyoon, Zhu Congcong, Meng Gaoyuan, Xia Weiming, Bennett David A, Lunetta Kathryn L, Ikezu Tsuneya, Au Rhoda, Stein Thor D, Farrer Lindsay A, Jun Gyungah R

Abstract excerpt

Mechanisms underlying the protective effect of apolipoprotein E (APOE) ε2 against Alzheimer disease (AD) are not well understood. We analyzed gene expression data derived from autopsied brains donated by 982 individuals including 135 APOE ɛ2/ɛ3 carriers. Complement pathway genes C4A and C4B were among the most significantly differentially expressed genes between ɛ2/ɛ3 AD cases and controls. We also identified an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34480088
DOI: 10.1038/s41380-021-01266-z
PMCID: PMC8758485

Genes

APOE
C4B
HSPA2
C4A

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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