Article

Thiazole substitution of a labile amide bond - a new option towards stable pantothenamide-mimics

2025-03-01

Abstract excerpt

<h4>ABSTRACT</h4> The emergence and spread of artemisinin-resistant, malaria-causing P. falciparum provide the impetus for the development of novel antimalarials. Pantothenamides are potent inhibitors of malaria parasite proliferation, however their clinical use is hindered by pantetheinase-mediated degradation in human serum. Here we report the synthesis and biological activity of a series of pantothenamide-mim...

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Literature Corpus work: c8aa178c-b0dd-5c75-802c-8d4d7037ac69
DOI: 10.1101/2025.02.25.640258

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