Article

Potent reaction hijacking inhibitors of <i>Plasmodium falciparum</i> asparagine tRNA synthetase

2026-05-15

Abstract excerpt

Malaria remains one of the major threats to human health. Breakthrough drugs with high potency and low resistance risk are needed to combat the ever-increasing resistance to currently deployed antimalarials. Here, we explore a series of 4-amino-quinazoline-based sulfonamides, with drug-like physicochemical parameters and a synthetically accessible scaffold. Exemplars exhibit nanomolar potency against blood stage...

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Literature Corpus work: 0c579319-595c-51c7-a17d-6b9ba2031baa
DOI: 10.64898/2026.05.15.725388

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