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Article

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues.

PLoS pathogens - 1 Apr 2018

Tjhin Erick T, Spry Christina, Sewell Alan L, Hoegl Annabelle, Barnard Leanne, Sexton Anna E, Siddiqui Ghizal, Howieson Vanessa M, Maier Alexander G, Creek Darren J, Strauss Erick, Marquez Rodolfo, Auclair Karine, Saliba Kevin J

Abstract excerpt

The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five enzymes, the first being a pantothenate kinase (PfPanK). Multiple antiplasmodial pantothenate analogues, including pantothenol and CJ-15,801, kill the parasite by targeting CoA biosynthesis/utilisation. Their mechanism of action, however,...

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Identifiers

PMID: 29614109
DOI: 10.1371/journal.ppat.1006918
PMCID: PMC5882169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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