Article

Antimalarial pantothenamide metabolites target acetyl-CoA synthesis in <i>Plasmodium falciparum</i>

2018-01-30

Abstract excerpt

Malaria eradication is critically dependent on novel drugs that target resistant Plasmodium parasites and block transmission of the disease. Here we report the discovery of potent pantothenamide bioisosteres that are active against blood-stage P. falciparum and also block onward mosquito transmission. These compounds are resistant to degradation by serum pantetheinases, show favorable pharmacokinetic properties...

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Identifiers and source

Literature Corpus work: 14677088-b3b1-5a6a-b4a0-f7fef0148718
DOI: 10.1101/256669

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