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Identification of α-azacyclic acetamide-based inhibitors of <i>P. falciparum</i> Na <sup>+</sup> pump ( <i>Pf</i> ATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening

2025-05-20

Abstract excerpt

<h4>ABSTRACT</h4> Malaria treatments are compromised by drug resistance, creating an urgent need to discover new drugs. We used a phenotypic high-throughput screening (HTS) platform to identify new antimalarials, uncovering three related pyrrole-, indole-, and indoline-based series with a shared α-azacyclic acetamide core. These compounds showed fast-killing activity on asexual blood-stage Plasmodium falciparum...

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Literature Corpus work
038c8026-4cb3-5565-a7d3-7b71e43f0850
DOI
10.1101/2025.05.20.655166
Open publication

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Identification of α-azacyclic acetamide-based inhibitors of <i>P. falciparum</i> Na <sup>+</sup> pump ( <i>Pf</i> ATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screeningDOI 10.1101/2025.05.20.655166
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