Article
Assessment of Mycobacterium tuberculosis pantothenate kinase vulnerability through target knockdown and mechanistically diverse inhibitors.
Antimicrobial agents and chemotherapy - 1 Jun 2014
Reddy B K Kishore, Landge Sudhir, Ravishankar Sudha, Patil Vikas, Shinde Vikas, Tantry Subramanyam, Kale Manoj, Raichurkar Anandkumar, Menasinakai Sreenivasaiah, Mudugal Naina Vinay, Ambady Anisha, Ghosh Anirban, Tunduguru Ragadeepthi, Kaur Parvinder, Singh Ragini, Kumar Naveen, Bharath Sowmya, Sundaram Aishwarya, Bhat Jyothi, Sambandamurthy Vasan K, Björkelid Christofer, Jones T Alwyn, Das Kaveri, Bandodkar Balachandra, Malolanarasimhan Krishnan, Mukherjee Kakoli, Ramachandran Vasanthi
Abstract excerpt
Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenate, the first committed and rate-limiting step toward coenzyme A (CoA) biosynthesis. In our earlier reports, we had established that the type I isoform encoded by the coaA gene is an essential pantothenate kinase in Mycobacterium tuberculosis, and this vital information was then exploited to screen large libraries for identification of...
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