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Antimalarial drug discovery: targeting protein kinases

14 Feb 2007

Abstract excerpt

Protein kinases (PKs) are prime targets for drug discovery in a variety of diseases, including cancer and neurodegenerative pathologies. The characterisation of the kinome of the human malaria parasite Plasmodium falciparum has revealed profound divergences, at several levels, between PKs of the parasite and those of its host. Here, the authors review the major issues and recent advances regarding the development...

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PMID: 17298288
DOI: 10.1517/14728222.11.3.279

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