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Identification of potent and selective <i>N</i> -myristoyltransferase inhibitors of <i>Plasmodium vivax</i> liver stage hypnozoites and schizonts

2023-01-28

Abstract excerpt

<h4>ABSTRACT</h4> New drugs targeting multiple stages of the malaria-causing parasite, Plasmodium , are needed to reduce and eliminate malaria worldwide. N -Myristoyltransferase (NMT) is an essential eukaryotic enzyme, and a validated chemically tractable drug target for malaria. Previous efforts have failed to target NMT owing to the low selectivity for the Plasmodium enzyme compared with human NMTs. Herein,...

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Literature Corpus work
1d7d2f78-22fa-5c10-a380-3547d5c10c1f
DOI
10.1101/2023.01.27.525941
Open publication

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