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Natural product-mediated reaction hijacking mechanism validates <i>Plasmodium</i> aspartyl-tRNA synthetase as an antimalarial drug target

2025-03-20

Abstract excerpt

Malaria poses an enormous threat to human health. With ever-increasing resistance to currently deployed antimalarials, new targets and starting point compounds with novel mechanisms of action need to be identified. Here, we explore the antimalarial activity of the Streptomyces sp natural product, 5ʹ- O -sulfamoyl-2-chloroadenosine (dealanylascamycin, DACM) and compare it with the synthetic adenosine monophosphat...

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Literature Corpus work
4d5bf476-d7d4-5004-b572-d36c7e1b7d1e
DOI
10.1101/2025.03.20.644283
Open publication

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Natural product-mediated reaction hijacking mechanism validates <i>Plasmodium</i> aspartyl-tRNA synthetase as an antimalarial drug targetDOI 10.1101/2025.03.20.644283
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