Article

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

2021-05-14

Abstract excerpt

Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (ACS) inhibitor to enter preclinical development. Our studies demonstrated attractive drug-like properties and in vivo efficacy in a humanized mouse model of Plasmodium falciparum infection. The compound showed exceptional in v...

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Literature Corpus work: b1c65339-302b-5b85-a9b3-d06d9098ad64
DOI: 10.1101/2021.05.12.443866

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