Article

Discovery and mechanism of a highly selective, antifungal acetyl CoA synthetase inhibitor

2025-01-01

Abstract excerpt

<title>Abstract</title> <p>Acetyl CoA synthetases (ACS) have emerged as drug targets for the treatment of cancer, metabolic diseases as well as fungal and parasitic infections. Although a variety of small molecule ACS inhibitors have been discovered, the systematic optimization of these molecules has been slowed by a lack of structural information regarding their mechanism of inhibition. Through a chemical geneti...

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Literature Corpus work: 5f8b4855-6984-5293-b666-4129b04bfdd2
DOI: 10.21203/rs.3.rs-5619443/v1

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