Article

A painless nerve growth factor variant uncouples nociceptive and neurotrophic TrkA signaling

2025-11-18

Abstract excerpt

Nerve growth factor (NGF) binding to the receptor tyrosine kinase, TrkA, drives neurotrophic signaling essential for neuronal development and survival. This interaction simultaneously drives peripheral pain, making this pathway an attractive but complicated therapeutic target for chronic pain. By integrating single-molecule microscopy, structural and electrophysiology analyses, with a human NGF variant, NGF painl...

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Literature Corpus work: c8546a8f-36a7-50cb-bc7a-97c86b6b389a
DOI: 10.1101/2025.11.18.686377

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