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Article

Understanding pain perception through genetic painlessness diseases: The role of NGF and proNGF.

Pharmacological research - 1 Jul 2021

Testa Giovanna, Cattaneo Antonino, Capsoni Simona

Abstract excerpt

Nerve growth factor (NGF), by binding to TrkA and p75NTR receptors, regulates the survival and differentiation of sensory neurons during development and mediates pain transmission and perception during adulthood, by acting at different levels of the nervous system. Key to understanding the role of NGF as a pain mediator is the finding that mutations (namely, R121W, V232fs and R221W) in the NGF gene cause...

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Source

Identifiers

PMID: 34000361
DOI: 10.1016/j.phrs.2021.105662

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Understanding pain perception through genetic painlessness diseases: The role of NGF and proNGF.PMID 34000361Read ↗

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