Article

Designed NGF mimetics with reduced nociceptive signatures in neurons

2025-04-14

Abstract excerpt

The clinical use of Nerve Growth Factor (NGF) for neuronal regeneration has been hampered by pain sensitization side effects. NGF signals through the receptor tyrosine kinase TrkA and the co-receptor p75 NTR ; pain sensitization is thought to involve p75 NTR . We sought to overcome this limitation by de novo design of a TrkA agonist that does not bind p75 NTR . We designed homodimeric TrkA engaging constructs t...

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Literature Corpus work: c3418f9f-27de-5379-8f7e-06706e4abfa9
DOI: 10.1101/2025.04.14.648806

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