Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity.

PloS one - 28 Feb 2011

Capsoni Simona, Covaceuszach Sonia, Marinelli Sara, Ceci Marcello, Bernardo Antonietta, Minghetti Luisa, Ugolini Gabriele, Pavone Flaminia, Cattaneo Antonino

Abstract excerpt

During adulthood, the neurotrophin Nerve Growth Factor (NGF) sensitizes nociceptors, thereby increasing the response to noxious stimuli. The relationship between NGF and pain is supported by genetic evidence: mutations in the NGF TrkA receptor in patients affected by an hereditary rare disease (Hereditary Sensory and Autonomic Neuropathy type IV, HSAN IV) determine a congenital form of severe pain insensitivity,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chick Embryo
Share to Hereditary Sensory and Autonomic Neuropathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Growth Factors

Share to PC12 Cells

Share to Receptor, Nerve Growth Factor

Share to Sensory Receptor Cells

Share to Tryptophan

Source

Open in PubMed Open full text

Identifiers

PMID: 21387003
DOI: 10.1371/journal.pone.0017321
PMCID: PMC3046150

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity.PMID 21387003Read ↗

Swedish Nerve Growth Factor Mutation (NGF <sup>R100W</sup> ) Defines a Role for TrkA and p75NTR in NociceptionSemantic proximity Read ↗

The NGFR100W Mutation Specifically Impairs Nociception without Affecting Cognitive Performance in a Mouse Model of Hereditary Sensory and Autonomic Neuropathy Type V.Semantic proximity Read ↗

Swedish Nerve Growth Factor Mutation (NGF R100W ) Defines a Role for TrkA and p75 NTR in NociceptionSemantic proximity Read ↗

Understanding pain perception through genetic painlessness diseases: The role of NGF and proNGF.Semantic proximity Read ↗

In vitro receptor binding properties of a "painless" NGF mutein, linked to hereditary sensory autonomic neuropathy type V.Semantic proximity Read ↗

From genes to pain: nerve growth factor and hereditary sensory and autonomic neuropathy type V.Semantic proximity Read ↗

A Missense Point Mutation in Nerve Growth Factor (NGF <sup>R100W</sup> ) Results in Selective Peripheral Sensory NeuropathySemantic proximity Read ↗

Functional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a "Painless" Lead Investigational Candidate for Therapeutic Applications.Semantic proximity Read ↗

Human TrkAR649W mutation impairs nociception, sweating and cognitive abilities: a mouse model of HSAN IV.Semantic proximity Read ↗

A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy.Semantic proximity Read ↗

A congenital pain insensitivity mutation in the nerve growth factor gene uncouples nociception from affective pain in heterozygous humans and miceSemantic proximity Read ↗

Single-Fiber Recordings of Nociceptive Fibers in Patients With HSAN Type V With Congenital Insensitivity to Pain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.