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Swedish Nerve Growth Factor Mutation (NGF R100W ) Defines a Role for TrkA and p75 NTR in Nociception

26 Feb 2018

Abstract excerpt

Nerve growth factor (NGF) exerts multiple functions on target neurons throughout development. The recent discovery of a point mutation leading to a change from arginine to tryptophan at residue 100 in the mature NGFβ sequence (NGF R100W ) in patients with hereditary sensory and autonomic neuropathy type V (HSAN V) made it possible to distinguish the signaling mechanisms that lead to two functionally different...

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PMID: 29483280
DOI: 10.1523/jneurosci.1686-17.2018

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