Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target.

doi:10.1126/scisignal.abm6046

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Article

Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target.

Science signaling - 26 Apr 2022

Moraes Beatriz C, Ribeiro-Filho Helder V, Roldão Allan P, Toniolo Elaine F, Carretero Gustavo P B, Sgro Germán G, Batista Fernanda A H, Berardi Damian E, Oliveira Victoria R S, Tomasin Rebeka, Vieceli Felipe M, Pramio Dimitrius T, Cardoso Alexandre B, Figueira Ana C M, Farah Shaker C, Devi Lakshmi A, Dale Camila S, de Oliveira Paulo S L, Schechtman Deborah

Abstract excerpt

Chronic pain is a major health issue, and the search for new analgesics has become increasingly important because of the addictive properties and unwanted side effects of opioids. To explore potentially new drug targets, we investigated mutations in the NTRK1 gene found in individuals with congenital insensitivity to pain with anhidrosis (CIPA). NTRK1 encodes tropomyosin receptor kinase A (TrkA), the receptor for...

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PMID: 35471943
DOI: 10.1126/scisignal.abm6046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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