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Article

Interaction between the transmembrane domains of neurotrophin receptors p75 and TrkA mediates their reciprocal activation.

The Journal of biological chemistry - 1 Aug 2021

Franco María L, Nadezhdin Kirill D, Light Taylor P, Goncharuk Sergey A, Soler-Lopez Andrea, Ahmed Fozia, Mineev Konstantin S, Hristova Kalina, Arseniev Alexander S, Vilar Marçal

Abstract excerpt

The neurotrophin receptors p75 and tyrosine protein kinase receptor A (TrkA) play important roles in the development and survival of the nervous system. Biochemical data suggest that p75 and TrkA reciprocally regulate the activities of each other. For instance, p75 is able to regulate the response of TrkA to lower concentrations of nerve growth factor (NGF), and TrkA promotes shedding of the extracellular domain...

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Identifiers

PMID: 34216618
DOI: 10.1016/j.jbc.2021.100926
PMCID: PMC8327350

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