Functional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a "Painless" Lead Investigational Candidate for Therapeutic Applications.

doi:10.1371/journal.pone.0136425

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Article

Functional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a "Painless" Lead Investigational Candidate for Therapeutic Applications.

PloS one - 1 Jan 2015

Malerba Francesca, Paoletti Francesca, Bruni Ercole Bruno, Materazzi Serena, Nassini Romina, Coppi Elisabetta, Patacchini Riccardo, Capsoni Simona, Lamba Doriano, Cattaneo Antonino

Abstract excerpt

BACKGROUND: Nerve Growth Factor (NGF) holds a great therapeutic promise for Alzheimer's disease, diabetic neuropathies, ophthalmic diseases, dermatological ulcers. However, the necessity for systemic delivery has hampered the clinical applications of NGF due to its potent pro-nociceptive action. A "painless" human NGF (hNGF R100E) mutant has been engineered. It has equal neurotrophic potency to hNGF but a lower...

Topics

Animals
Cell Differentiation
Cell Line, Tumor
Cell Proliferation
Escherichia coli
Humans
Kinetics
Mutation
Nerve Growth Factor
Oligodendroglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pain

Protein Engineering

Protein Precursors

Protein Stability

Proteolysis

Rats

Receptor, Nerve Growth Factor

Receptor, trkA

Source

Open in PubMed Open full text

Identifiers

PMID: 26371475
DOI: 10.1371/journal.pone.0136425
PMCID: PMC4570711

Genes

Variants

Provenance

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