Article

Unraveling the distinct motion bias of TrkA-NGF complex in NGF <sup>R100W</sup> -driven HSAN V disease

2025-02-27

Abstract excerpt

<h4>ABSTRACT</h4> Nerve growth factor (NGF), which binds to tropomyosin-related kinase A (TrkA) receptor, plays essential roles in neuronal survival and function and is also a potent mediator of pain sensation. Mutations in NGF , particularly NGF R100W , cause hereditary sensory autonomic neuropathy V (HSAN V), which is characterized by insensitivity to pain but without impairment of neurotrophin function. Even...

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Literature Corpus work: f7ee0dc2-797c-54a0-8c9c-74f51fe7f2f4
DOI: 10.1101/2025.02.27.640519

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