Article

Swedish Nerve Growth Factor Mutation (NGF <sup>R100W</sup> ) Defines a Role for TrkA and p75NTR in Nociception

2018-02-16

Abstract excerpt

Nerve growth factor (NGF) exerts multiple functions on target neurons throughout development. The recent discovery of a point mutation leading to a change from arginine to tryptophan at residue 100 in the mature NGFβ sequence (NGF R100W ) in patients with hereditary sensory and autonomic neuropathy, type V (HSAN V), made it possible to distinguish the signaling mechanisms that lead to two functionally different o...

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Literature Corpus work: ecaee514-3286-519e-8111-cf6d842b320a
DOI: 10.1101/266643

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