Article

Unveiling functional motions based on point mutations in biased signaling systems: A normal mode study on Nerve Growth Factor bound to TrkA

2019-03-20

Abstract excerpt

Many receptors elicit signal transduction by activating multiple intracellular pathways. This transduction may be triggered by a nonspecific ligand, which simultaneously activates all receptor’s signaling paths. In addition, the binding of a biased ligand preferentially elicits one path over another, in a process called biased signaling. Identifying the functional motions related to each one of these distinct path...

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Literature Corpus work: 8893247c-d451-5104-baa7-5361050adf9f
DOI: 10.1101/584300

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