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Article

Comparison of nerve growth factor receptor binding models using heterodimeric muteins.

Journal of neuroscience research - 1 Dec 2012

Mehta Hrishikesh M, Woo Sang B, Neet Kenneth E

Abstract excerpt

Nerve growth factor (NGF) is a homodimer that binds to two distinct receptor types, TrkA and p75, to support survival and differentiation of neurons. The high-affinity binding on the cell surface is believed to involve a heteroreceptor complex, but its exact nature is unclear. We developed a heterodimer (heteromutein) of two NGF muteins that can bind p75 and TrkA on opposite sides of the heterodimer, but not two...

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Source

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Identifiers

PMID: 22903500
DOI: 10.1002/jnr.23116
PMCID: PMC3674885

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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