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Human TrkAR649W mutation impairs nociception, sweating and cognitive abilities: a mouse model of HSAN IV.

Human molecular genetics - 6 Apr 2023

Pacifico Paola, Testa Giovanna, Amodeo Rosy, Mainardi Marco, Tiberi Alexia, Convertino Domenica, Arevalo Juan Carlos, Marchetti Laura, Costa Mario, Cattaneo Antonino, Capsoni Simona

Abstract excerpt

A functional nerve growth factor NGF-Tropomyosin Receptor kinase A (TrkA) system is an essential requisite for the generation and maintenance of long-lasting thermal and mechanical hyperalgesia in adult mammals. Indeed, mutations in the gene encoding for TrkA are responsible for a rare condition, named Hereditary Sensory and Autonomic Neuropathy type IV (HSAN IV), characterized by the loss of response to noxious...

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PMID: 36537577
DOI: 10.1093/hmg/ddac295
PMCID: PMC10077510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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