Systematic Analysis of Targets of Pumilio (PUM)-Mediated mRNA Decay Identifies a Role of PUM1 in Regulating DNA Damage Response Pathway

Abstract excerpt

<h4>Summary</h4> RNA-binding proteins (RBPs) play a pivotal role in gene expression by modulating the stability of transcripts; however, the identification of degradation targets of RBPs remains difficult. Here, we identified 48 target mRNAs of human Pumilio 1 (PUM1), an evolutionally conserved RBP, by combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs to PUM1. Here, we developed an...

Topics

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• 3' Untranslated Regions
• Cytoplasm
• Cytoskeletal Proteins
• Nucleic Acid Conformation
• Regulatory Factor X Transcription Factors
• RNA Splicing
• RNA Stability
• X-Box Binding Protein 1

Identifiers and source

Literature Corpus work

c7cba3fa-a58e-5e47-aeb5-31aebef63276

DOI

10.1101/387381