Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.

doi:10.1007/s11033-017-4139-7

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Article

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.

Molecular biology reports - 1 Feb 2018

Gupta Puneet, Li Yan-Ruide

Abstract excerpt

Over 10% of genetic diseases are caused by mutations that introduce a premature termination codon in protein-coding mRNA. Nonsense-mediated mRNA decay (NMD) is an essential cellular pathway that degrades these mRNAs to prevent the accumulation of harmful partial protein products. NMD machinery is also increasingly appreciated to play a role in other essential cellular functions, including telomere homeostasis and...

Topics

Carrier Proteins
Codon, Nonsense
Humans
Mutation
Nonsense Mediated mRNA Decay
Protein Biosynthesis
RNA Helicases
RNA Stability
RNA, Messenger
Trans-Activators
Transcription Factors

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PMID: 29282598
DOI: 10.1007/s11033-017-4139-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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