Article

Principles of mRNA control by human PUM proteins elucidated from multi-modal experiments and integrative data analysis

2020-04-01

Abstract excerpt

The human PUF-family proteins, PUM1 and PUM2, post-transcriptionally regulate gene expression by binding to a PUM recognition element (PRE) in the 3’ UTR of target mRNAs. Hundreds of PUM1/2 targets have been identified from changes in steady state RNA levels; however, prior studies could not differentiate between the contributions of changes in transcription and RNA decay rates. We applied metabolic labeling to me...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e0bda562-cb52-582e-935a-2d05f38bfd97
DOI: 10.1101/2020.04.01.019836

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Principles of mRNA control by human PUM proteins elucidated from multi-modal experiments and integrative data analysisDOI 10.1101/2020.04.01.019836Read

A quantitative and predictive model for RNA binding by human Pumilio proteinsSemantic proximity Read

A comprehensive thermodynamic model for RNA binding by the Saccharomyces cerevisiae Pumilio protein PUF4Semantic proximity Read

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated transcriptome in human cellsSemantic proximity Read

Systematic Analysis of Targets of Pumilio (PUM)-Mediated mRNA Decay Identifies a Role of PUM1 in Regulating DNA Damage Response PathwaySemantic proximity Read

Target selection by natural and redesigned PUF proteins.Semantic proximity Read

Patterns and plasticity in RNA-protein interactions enable recruitment of multiple proteins through a single site.Semantic proximity Read

An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decaySemantic proximity Read

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptomeSemantic proximity Read

Novel insights into global translational regulation through Pumilio family RNA-binding protein Puf3p revealed by ribosomal profiling.Semantic proximity Read

Plant PUF RNA-binding proteins: A wealth of diversity for post-transcriptional gene regulation.Semantic proximity Read

Systematic Identification of Post-Transcriptional Regulatory ModulesSemantic proximity Read

Divergent RNA binding specificity of yeast Puf2p.Semantic proximity Read