Article
HITS-CLIP analysis of human ALKBH8 points towards its role in tRNA and noncoding RNA regulation
2022-01-17
Abstract excerpt
Transfer RNAs acquire a large plethora of chemical modifications. Among those, modifications of the anticodon loop play important roles in translational fidelity and tRNA stability. Four human wobble U containing tRNAs obtain 5-methoxycarbonylmethyluridine (mcm 5 U 34 ) or 5-methoxycarbonylmethyl-2-thiouridine (mcm 5 s 2 U 34 ), which play a role in decoding. This mark involves a cascade of enzymatic activiti...
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Identifiers and source
- Literature Corpus work
- cee2793e-2d83-5ad1-98e6-cddee00e01a5
- DOI
- 10.1101/2022.01.17.476611