Different alterations in mRNP composition trigger an increase in harmful R-loops

Abstract excerpt

Understanding how the assembly of nascent mRNA into a ribonucleoprotein (mRNP) influences R-loop homeostasis is crucial for gaining insight into the cellular mechanisms that prevent genome instability. Here, we identify three RNA-binding proteins, Rie1, Rim4 and She2, whose stoichiometry is important to limit R-loop accumulation and, thus, to prevent DNA damage. Interestingly, Rim4 and She2 are overrepresented in...

Topics

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• Base Pairing
• DNA Repair Mechanisms
• DNA, Single-Stranded
• Gene Expression Regulation
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genetic Therapy
• RNA

Identifiers and source

Literature Corpus work

e829a134-0633-50fb-98ae-7a21076260f7

DOI

10.1101/2024.11.11.622913