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Acute Degradation of Pumilio Proteins Uncovers a Biphasic Post-transcriptional Regulatory Hierarchy Controlling Embryonic Stem Cell Fate Decisions

2026-03-11

Abstract excerpt

<h4>SUMMARY</h4> Post-transcriptional regulation is critical for mammalian embryogenesis yet has been underexplored. We previously showed that RNA-binding Pumilio proteins (Pum1/2) are essential for early mouse embryogenesis and embryonic stem cell (ESC) functions. Here, using acute protein degradation systems combined with time-resolved RNA-seq and eCLIP, we delineate a two-phase regulatory hierarchy modulated b...

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Literature Corpus work: d6661ce8-2759-5e43-864b-2424a8cffa06
DOI: 10.64898/2026.03.10.710821

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