Article
hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1.
Nature - 26 Mar 2015
Sugimoto Yoichiro, Vigilante Alessandra, Darbo Elodie, Zirra Alexandra, Militti Cristina, D'Ambrogio Andrea, Luscombe Nicholas M, Ule Jernej
Abstract excerpt
The structure of messenger RNA is important for post-transcriptional regulation, mainly because it affects binding of trans-acting factors. However, little is known about the in vivo structure of full-length mRNAs. Here we present hiCLIP, a biochemical technique for transcriptome-wide identification of RNA secondary structures interacting with RNA-binding proteins (RBPs). Using this technique to investigate RNA...
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