Article

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome

2020-11-18

Abstract excerpt

Pumilio paralogs, PUM1 and PUM2, are sequence-specific RNA-binding proteins that are essential for vertebrate development and neurological functions. PUM1&2 negatively regulate gene expression by accelerating degradation of specific mRNAs. Here, we determined the repression mechanism and impact of human PUM1&2 on the transcriptome. We identified subunits of the CCR4-NOT (CNOT) deadenylase complex required for stab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9fa4d51-16db-5b85-af10-95e63a4dd149
DOI: 10.1101/2020.11.17.387456

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptomeDOI 10.1101/2020.11.17.387456Read

Human Pumilio proteins use fuzzy multivalent hydrophobic interactions to recruit the CCR4–NOT deadenylase complex to repress mRNAsSemantic proximity Read

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated transcriptome in human cellsSemantic proximity Read

A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cellsSemantic proximity Read

Systematic Analysis of Targets of Pumilio (PUM)-Mediated mRNA Decay Identifies a Role of PUM1 in Regulating DNA Damage Response PathwaySemantic proximity Read

Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1bSemantic proximity Read

Discovery of a Well-Folded Protein Interaction Hub Within the Human Long Non-Coding RNA <i>NORAD</i>Semantic proximity Read

Acute Degradation of Pumilio Proteins Uncovers a Biphasic Post-transcriptional Regulatory Hierarchy Controlling Embryonic Stem Cell Fate DecisionsSemantic proximity Read

An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decaySemantic proximity Read

The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation.Semantic proximity Read

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2.Semantic proximity Read

Phosphorylation-dependent tuning of mRNA deadenylation ratesSemantic proximity Read

Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain.Semantic proximity Read