Article

Binding of ApoE isoforms to Aβ peptides and effects on their fibrillization

2025-11-12

Abstract excerpt

<title>Abstract</title> <p> Alzheimer’s disease (AD) is the most widespread neurodegenerative disease, strongly linked to amyloid depositions in the brain consisting of amyloid beta (Aβ) peptides. The likelihood of developing late-onset Alzheimer’s disease (LOAD) is influenced by the specific isoforms of apolipoprotein E (ApoE), with ApoE4 being the strongest known genetic risk factor for LOAD. Strong evidence s...

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Literature Corpus work: c6093137-5532-54aa-b2db-18b5f0a662cb
DOI: 10.21203/rs.3.rs-8086961/v1

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