Article

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease

2021-07-14

Abstract excerpt

Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance of direct interactions between apoE and amyloid-β (Aβ) remains controversial. Here, single-molecule imaging shows that all isoforms of apoE associate with Aβ in the early stages of aggregation and then fa...

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Literature Corpus work: 512b5bce-a712-5559-a55a-00d459f563a6
DOI: 10.1101/2021.07.13.452239

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