Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: implications for disease pathogenesis.

doi:10.1006/bbrc.1995.1389

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Article

Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: implications for disease pathogenesis.

Biochemical and biophysical research communications - 17 Mar 1995

Richey P L, Siedlak S L, Smith M A, Perry G

Abstract excerpt

Apolipoprotein E (ApoE) genotype is a significant risk factor for the development of Alzheimer disease (AD) and the ApoE protein is associated with senile plaques (SP) and neurofibrillary tangles (NFT), the pathological lesions of AD. Despite this data, the relevance of ApoE to the disease pathog...

Topics

Alzheimer Disease
Amyloid beta-Peptides
Apolipoproteins E
Genotype
Hippocampus
Humans
Neurofibrillary Tangles
Neurons
tau Proteins

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