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Article

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

25 Apr 2013

Abstract excerpt

Apolipoprotein E gene (APOE) alleles may shift the onset of Alzheimer's disease (AD) through apoE protein isoforms changing the probability of amyloid-β (Aβ) accumulation. It has been proposed that differential physical interactions of apoE isoforms with soluble Aβ (sAβ) in brain fluids influence the metabolism of Aβ, providing a mechanism to account for how APOE influences AD risk. In contrast, we provide clear...

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PMID: 23620513
DOI: 10.1073/pnas.1220484110

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