Article

ApoE lipidation, not isoform, is the key modulator of Aβ interaction, uptake, and cytotoxicity

2025-11-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Inherited variations in the Apolipoprotein E ( APOE ) gene are the largest genetic determinant for late-onset Alzheimer’s Disease, with the APOEε4 allele conferring the highest risk. While APOE was shown to modulate amyloid beta (Aβ) pathology in a genotype-specific manner ( APOEε4 > APOEε3 > APOEε2 ), it remains an important open question whether these differences are...

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Literature Corpus work: c3571a93-0160-5be7-95d3-94b1df95e06b
DOI: 10.1101/2025.11.19.685371

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