Article

Functional insights from biophysical study of TREM2 interactions with ApoE and Aβ <sub>1-42</sub>

2020-02-25

Abstract excerpt

<h4>INTRODUCTION</h4> TREM2 is an innate immune receptor expressed on myeloid cells including microglia in the brain. How TREM2 engages different ligands remains poorly understood. <h4>METHODS</h4> We used comprehensive BLI analysis to investigate the TREM2 interactions with ApoE and monomeric amyloid beta (mAβ42). <h4>RESULTS</h4> TREM2 binding did not depend on ApoE lipidation, and there were only slight diff...

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Literature Corpus work: e1a4068d-b9c0-5d88-9456-e5856ad0827c
DOI: 10.1101/2020.02.24.963264

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