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Article

APOE Genotype Difference in the Biphasic Modulation of Amyloid-β Aggregation by Direct Binding and Lowering the Nucleation Barrier.

Biomacromolecules - 8 Dec 2025

Song Zhiyuan, Bhandari Kamal, Hou Tianyi, Ding Feng

Abstract excerpt

Amyloid-β (Aβ) aggregation is a hallmark of Alzheimer's disease (AD), while the apoE4 isoform (C112R) represents the strongest genetic risk factor. We combined binding-site mapping and discrete molecular dynamics (DMD) simulations to elucidate isoform-specific apoE-Aβ interactions. Computational peptide-array analysis identified Aβ-binding hotspots in the apoE4 N-terminal domain (NTD) around R112, conferring...

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Identifiers

PMID: 41185093
DOI: 10.1021/acs.biomac.5c01323
PMCID: PMC12709511

Genes

APOE
DMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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