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New plasma LC-MS/MS assays for the quantitation of beta-amyloid peptides and identification of apolipoprotein E proteoforms for Alzheimer’s disease risk assessment

2023-11-22

Abstract excerpt

<h4>Objectives</h4> Early detection of Alzheimer’s disease (AD) represents an unmet clinical need. Beta-amyloid (Aβ) plays an important role in AD pathology, and the Aβ42/40 peptide ratio is a good indicator for amyloid deposition. In addition, variants of the APOE gene are associated with variable AD risk. Here we describe the development and validation of high-throughput liquid chromatography-tandem mass spectro...

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Literature Corpus work
2ea26bd6-3187-5ec5-8ac0-b0de949ded75
DOI
10.1101/2023.11.20.23298532
Open publication

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New plasma LC-MS/MS assays for the quantitation of beta-amyloid peptides and identification of apolipoprotein E proteoforms for Alzheimer’s disease risk assessmentDOI 10.1101/2023.11.20.23298532
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