Article

ApoE4 accelerates the condensate to amyloid transition of tau

2025-11-25

Abstract excerpt

Aberrant liquid to solid transition (LST) of tau is a pathological hallmark of several tauopathies, most notably Alzheimer’s disease (AD). ApoE4 is a major genetic risk factor for AD and has been shown to exacerbatetau pathology, although the underlying mechanismremains unclear. Herewe investigate whether apoE isoforms can influenceamyloid aggregation of tau occurring via the liquid–liquid phase separation (LLPS)...

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Literature Corpus work: 682ad9b7-187b-5b74-a5ef-b18658e16999
DOI: 10.1101/2025.11.22.689889

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