Article
APOE and Alzheimer's Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer's Pathogenesis.
Molecular neurobiology - 1 Apr 2019
Uddin Md Sahab, Kabir Md Tanvir, Al Mamun Abdullah, Abdel-Daim Mohamed M, Barreto George E, Ashraf Ghulam Md
Abstract excerpt
Alzheimer's disease (AD) is an immutable neurodegenerative disease featured by the two hallmark brain pathologies that are the extracellular amyloid ß (Aß) and intraneuronal tau protein. People carrying the APOE4 allele are at high risk of AD concerning the ones carrying the ε3 allele, while the ε2 allele abates risk. ApoE isoforms exert a central role in controlling the transport of brain lipid, neuronal...
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