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Article

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk.

Molecular neurodegeneration - 4 Jan 2014

Tai Leon M, Mehra Shipra, Shete Varsha, Estus Steve, Rebeck G William, Bu Guojun, LaDu Mary Jo

Abstract excerpt

The APOE4 allele of apolipoprotein E (apoE) is the greatest genetic risk factor for Alzheimer's disease (AD) compared to APOE2 and APOE3. Amyloid-β (Aβ), particularly in a soluble oligomeric form (oAβ), is considered a proximal cause of neurodegeneration in AD. Emerging data indicate that levels of soluble oAβ are increased with APOE4, providing a potential mechanism of APOE4-induced AD risk. However, the...

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Source

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Identifiers

PMID: 24386905
DOI: 10.1186/1750-1326-9-2
PMCID: PMC3897976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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