Article

APOEε4 potentiates Aβ effects on longitudinal tangle accumulation via tau phosphorylation

2023-01-20

Abstract excerpt

<title>Abstract</title> <p>The mechanisms by which the apolipoprotein E <italic>ε4</italic> (<italic>APOE</italic>ε4) allele influences Alzheimer’s disease (AD) pathophysiological progression are poorly understood. Here, we tested the association of <italic>APOE</italic>ε4 carriership and amyloid-β (Aβ) burden with longitudinal tau pathology progression. We studied 104 individuals across the aging and AD spectrum...

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Literature Corpus work: 4e783d3c-521d-558e-b88d-ac9321760de4
DOI: 10.21203/rs.3.rs-2391695/v1

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