Article

The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing

2024-12-20

Abstract excerpt

<h4>Summary</h4> Protein arginine methyltransferase 5 (PRMT5) is a promising cancer target, yet it’s unclear which PRMT5 roles underlie this vulnerability. Here, we establish that PRMT5 inhibition induces a special class of unspliced introns, called detained introns (DIs). To interrogate the impact of DIs, we depleted CLNS1A, a PRMT5 cofactor that specifically enables Sm protein methylation. We found that many, b...

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Literature Corpus work: c4e4643e-d1db-5f35-a401-85461a1f818a
DOI: 10.1101/2024.12.17.628905

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