Article

PRMT5-exacerbating tumor stemness and immunosuppression confer a novel immunotherapeutic vulnerability in aggressive prostate cancer

2023-02-08

Abstract excerpt

<title>Abstract</title> <p>Protein arginine methylation is a common post-translational modification (PTM) catalyzed by nine protein arginine methyltransferases (PRMTs). As the major symmetric arginine methyltransferase that methylates both histone and non-histone substrates, PRMT5 plays key roles in a number of biological processes critical for development and tumorigenesis. PRMT5 overexpression has been reported...

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Literature Corpus work: 2a3de800-4671-57f3-af20-b919c158edf1
DOI: 10.21203/rs.3.rs-2487999/v1

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