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Article

Protein arginine methyltransferase (PRMT8) in cancer: Genomic alterations, subcellular dynamics, and clinical implications.

Critical reviews in oncology/hematology - 1 Oct 2026

Ting Choo-Yuen, Loon Sheron Goh Sir, Sun Lee Bee, Pin Kee Boon

Abstract excerpt

PRMT8 encodes a protein arginine methyltransferase, which is primarily expressed in the brain and nervous system. Several studies have reported its alterations, which have been implicated in various cancers. However, the existing information remains unsystematic and fragmented due to inconsistency in methodology. This review aims to explore PRMT8 gene alterations in humans, their effects on cellular function and...

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Topics

Humans
Protein-Arginine N-Methyltransferases
Neoplasms
Signal Transduction
Gene Expression Regulation, Neoplastic
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Animals

Prognosis

Membrane Proteins

Source

Identifiers

PMID: 42472561
DOI: 10.1016/j.critrevonc.2026.105493

Genes

PRMT8
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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