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Article

Protein Arginine Methyltransferase 5 (PRMT5) Mutations in Cancer Cells.

International journal of molecular sciences - 23 Mar 2023

Rasheed Shayaan, Bouley Renee A, Yoder Ryan J, Petreaca Ruben C

Abstract excerpt

Arginine methylation is a form of posttranslational modification that regulates many cellular functions such as development, DNA damage repair, inflammatory response, splicing, and signal transduction, among others. Protein arginine methyltransferase 5 (PRMT5) is one of nine identified methyltransferases, and it can methylate both histone and non-histone targets. It has pleiotropic functions, including...

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PMID: 37047013
DOI: 10.3390/ijms24076042
PMCID: PMC10094674

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