Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of recurrent somatic mutations that alter conserved m6A motifs in human cancer.

NAR cancer - 1 Jun 2025

Artz Oliver, White James R, Rousseau Benoit, Argiles Guillem, Foote Michael B, Johannet Paul, Patel Miteshkumar, Abdelfattah Somer, Patel Shrey, Wilde Callahan, Mieles David, Diaz Luis A

Abstract excerpt

N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotes and plays a key role in cellular growth and development. Global changes in cellular methylated RNA and m6A-mediated transcript regulation significantly impact oncogenesis. Here, we investigate how recurrent synonymous and non-synonymous somatic mutations abolishing individual canonical methylated m6A motifs affect transcript...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 40271220
DOI: 10.1093/narcan/zcaf014
PMCID: PMC12015683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of recurrent somatic mutations that alter conserved m6A motifs in human cancer.PMID 40271220Read ↗

Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer typesSemantic proximity Read ↗

Exploring the role of m6A modification in cancerSemantic proximity Read ↗

Systematic identification of tissue-conserved m <sup>6</sup> A sites reveals a stable epitranscriptomic regulatory layer controlling essential genesSemantic proximity Read ↗

Mutations in m6A consensus motifs are suppressed in the m6A modified genes in human cancer cells.Semantic proximity Read ↗

A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth.Semantic proximity Read ↗

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer.Semantic proximity Read ↗

The three YTHDF paralogs and VIRMA are the major tumor drivers among the m <sup>6</sup> A core genes in a pan-cancer analysisSemantic proximity Read ↗

Motif Disruption Domains Lead To Cancer Gene Expression RewiringSemantic proximity Read ↗

Allele-specific RNA N 6-methyladenosine modifications reveal functional genetic variants in human tissues.Semantic proximity Read ↗

Comprehensive analysis across mammalian tissues and cells decipher the underlying mechanism of m6A specificitySemantic proximity Read ↗

N <sup>6</sup> -Methyladenine DNA Modification in Human GenomeSemantic proximity Read ↗

Pan-cancer Analysis Reveals m <sup>6</sup> A Variation and Cell-specific Regulatory Network in Different Cancer TypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.